Bioactive Small Molecules
Medchemexpress LLC α-Amylase-IN-1 | 148404-10-8 | 98.3% | 310.35 | 5 MG
α-Amylase-IN-1 is a potent α-amylase inhibitor that also exhibits antioxidant activity. This compound is valuable for research into diabetes and various oxidative stress-related diseases.
- Potent α-amylase inhibitor
- Possesses antioxidant activity
- Used in the study of diabetes
- Used in the study of oxidative stress-related diseases
- For research use only
- Stable under recommended storage conditions
Medchemexpress LLC Methanone, (2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(2-methoxyphenyl)- (9CI) | 886536-76-1 | 99.1% | 354.31 | 25 MG
NCGC00351170 is an antiplatelet agent that disrupts the calcium and integrin-binding protein 1 (CIB1)-αIIbβ3 interaction. It inhibits thrombin-induced human platelet aggregation.
- Antiplatelet agent
- Disrupts CIB1-αIIbβ3 interaction
- Inhibits thrombin-induced human platelet aggregation
- For research use only
Medchemexpress LLC CHMFL-FLT3-122 | 1839150-56-9 | 98.5% | 471.55 | 1 ML
CHMFL-FLT3-122 is a potent, selective, and orally active FLT3 kinase inhibitor with an IC50 of 40 nM. It demonstrates selectivity for FLT3 over BTK and c-KIT kinases. This compound induces apoptosis by arresting the cell cycle in the G0/G1 phase and has shown to significantly inhibit the proliferation of FLT3-ITD positive acute myeloid leukemia (AML) cancer cell lines in in vitro studies. In in vivo studies, it suppressed tumor progression without significantly affecting body weight.
- Potent and selective FLT3 kinase inhibitor
- Orally active
- Induces apoptosis by arresting cell cycle in G0/G1 phase
- Inhibits proliferation of FLT3-ITD positive AML cell lines
- Inhibits FLT3 auto-phosphorylation, Stat5, ERK, AKT phosphorylation, and cMYC expression
- Suppresses tumor progression in in vivo models
Selleck Chemical LLC Mal-PEG4-NHS ester S0654-5MG
Mal-PEG4-NHS ester is a non-cleavable ADC linker containing a Maleimide group 4-unit PEG and an NHS ester
Apexbio Technology LLC Epinephrine HCl, 5g Cas# 55-31-2
Epinephrine HCl is a hormone and a neurotransmitter. 55-31-2. MFCD00801067 Epinephrine HCl is a hormone and a neurotransmitter. There are other sizes available. Please inqury us for quote.
Medchemexpress LLC HY-W011082 50mg Medchemexpress, NLRP3-IN-2 CAS:16673-34-0 Purity:>98%
Medchemexpress, HY-W011082 50mg NLRP3-IN-2 CAS:16673-34-0 NLRP3-IN-2, an intermediate substrate in the synthesis of glyburide, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size following myocardial ischemia/reperfusion in the mouse, without affecting glucose metabolism. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 1443246-62-5 | Medchem Express | ML 297 | 5mg | 506403686 | HY-110192 | MFCD27977571 | 328.323 | C17H14F2N4O
Ambeed | 3-(1-((Benzyloxy)carbonyl)piperidin-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid | 100mg | 490553026 | A312735 | 195877-90-8 | MFCD02179070 | 406.479 | C21H30N2O6
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eMolecules 2165322-94-9 | Medchem Express | USP25/28 inhibitor AZ1 | 5mg | 495799959 | HY-117370 | 422.218 | C17H16BrF4NO2
Medchem Express | IR415 | 5mg | 572596587 | HY-116999 | 452967-14-5 | MFCD00238878 | 296.340 | C13H14F2N4S
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Medchemexpress LLC GNE-131 | 1629063-81-5 | 98.2% | 442.57 | 1 ML
GNE-131 is a potent and selective inhibitor of human sodium channels, specifically targeting NaV1.7 with an IC50 of 3 nM. This compound has demonstrated excellent potency and good in vitro metabolic stability. It also exhibits low in vivo clearance in mouse, rat, and dog models, along with excellent efficacy in a transgenic mouse model of induced pain.
- Potent and selective sodium channel inhibition.
- Good metabolic stability in laboratory settings.
- Effective in pain models.
- Low clearance in multiple animal species.
![Medchemexpress LLC Phenol, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]- | 2009273-67-8 | 99.9% | 330.38 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000439827-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Phenol, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]- | 2009273-67-8 | 99.9% | 330.38 | 100 MG
GNE-6640 is a selective and non-covalent inhibitor of ubiquitin specific peptidase 7 (USP7). It has IC50 values of 0.75 μM for full length USP7, 0.43 μM for USP7 catalytic domain, 20.3 μM for full length USP47, and 0.23 μM for Ub-MDM2.
- Promotes endogenous MDM2 ubiquitination with Lys48 (K48)-linked polyubiquitin chains.
- Targets cellular USP7, MDM2, and p53 signaling pathways.
- Decreases viability of 108 cell lines with IC50 ≤ 10 μM.
- Can be combined with doxorubicin or cisplatin to enhance USP7 inhibitor efficacy.
- Induces tumor cell death.
- Enhances cytotoxicity with chemotherapeutic agents and targeted compounds.
Cayman Chemical L,L-Dityrosine, Purity: ≥90%, CAS: 63442-81-9, 5 mg
An amino acid conjugate; cross-links of it can form between fibrinogen molecules in the presence of hematin and plasma-generated hydrogen peroxide under non-thermal plasma exposure; cross-links of it can form between human amylin peptides in the presence of copper (II) ions and hydrogen peroxide
Cayman Chemical IT-901, Purity: ≥98%, CAS: 1584121-99-2, 1 mg
An inhibitor of the NF-κB subunit c-Rel; inhibits NF-κB DNA binding (IC50 = 0.1 µM); reduces TNF-α-induced NF-κB activity (IC50 = 4 µM); decreases proliferation of ABC and GCB DLBCLL cells at 3 µM; increases HO-1 expression and ROS production in mitochondria of DLBCL cells but not normal leukocytes; increases survival in a mouse model of GVHD at 24 mg/kg every other day beginning eight days after HSCT; reduces tumor growth in mouse xenograft models of EBV-induced B cell lymphoma, CLL, and Richter syndrome
Apexbio Technology LLC HhAntag 496794-70-8 50mg
HhAntag (CAS 496794-70-8) is a small molecule antagonist of the Hedgehog (Hh) signaling pathway which is implicated in ligand-dependent pathway activation associated with tumorigenesis in various human tissues Compared to cyclopamine HhAntag demonstrates approximately tenfold greater potency in inhibiting Hh pathway activity across a broad panel of cancer cell lines with growth-inhibitory IC50 values ranging from 2 M to over 30 M In vivo oral administration of HhAntag delays tumor growth in mouse models bearing primary human xenografts with observed tumor growth inhibition in pancreatic and colon adenocarcinoma models These findings support the use of HhAntag in investigating Hh-mediated oncogenesis and evaluating Hh pathway antagonism in preclinical cancer research
Medchemexpress LLC 6X His-tag (C-terminal) Antibody (YA860) | 50 UL
The Anti-6X His-tag (C-terminal) Antibody is a non-conjugated, mouse-originated IgG2a monoclonal antibody specifically designed to target 6X His-tag. This antibody is intended for research use only.
- Host: Mouse
- Clonality: Monoclonal
- Species independent reactivity
- Immunogen: Synthetic peptide corresponding to His-tag
- Conjugation: Non-conjugated
- Isotype: IgG2a
- Appearance: Liquid
- Formulation: Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol with 0.05% Sodium Azide as preservative
- Storage and stability: Stored at -20°C for 1 year, avoid repeated freeze/thaw cycles
- Shipping: With blue ice
- Applications: Western Blot (WB), Immunoprecipitation (IP)
- Predicted molecular weight: 30 kDa
- Observed molecular weight: 32 kDa
Medchemexpress LLC Azapropazone 5mg | 13539-59-8 | 300.36 g/mol | C16H20N4O2 | 5 MG
Azapropazone is a nonsteroidal anti-inflammatory drug (NSAID) supplied as an analytical research standard for non-clinical biochemical and pharmacological studies. It is used in research on rheumatoid arthritis and other inflammatory rheumatic conditions.
- High purity, 99.7% (HPLC), suitable for analytical applications.
- Molecular weight 300.36 g/mol and formula C16H20N4O2 for exact mass-based calculations.
- Available in small milligram quantities for assay development and reference standards.
- Soluble in common organic solvents for preparation of stock solutions.